Table 1.
Clinical trials of stem cell transplantation in the subacute phase of SCI
| Study | Stem cell type | Tx. time from SCI | SCI site | PreTx. AIS | N | PostTx. AIS | N |
|---|---|---|---|---|---|---|---|
| Shin et al. [47] (2015) | NSPCs | 63.4±54.1 (18–213) days | Cervical | A | 17 | A→A | 14 |
| A→B | 1 | ||||||
| A→C | 2 | ||||||
| B | 2 | B→D | 2 | ||||
| Anderson et al. [2] (2017) | SCs | 40.2±11.3 (29–59) days | Thoracic | A | 6 | A→A | 5 |
| A→B | 1 | ||||||
| Saito et al. [45] (2012) | BM-MSCs | 13.0±2.9 (8–17) days | Cervical | A | 3 | A→A | 3 |
| B | 1 | B→D | 1 | ||||
| C | 1 | C→D | 1 | ||||
| Karamouzian et al. [23] (2012) | BM-MNCs | 27.3±8.4 (14–43) days | Thoracic | A | 11 | A→A | 6 |
| A→C | 5 | ||||||
| Park et al. [40] (2005) | BM-MCP+GM-CSF | 9.8±2.9 (7–14) days | Cervical | A | 4 | A→A | 1 |
| A→B | 1 | ||||||
| A→C | 2 | ||||||
| 8 days | Thoracic | A | 1 | A→C | 1 | ||
| Knoller et al. [27] (2005) | Activated autologous macrophages | 12.3±1.9 (9–14) days | Cervical | A | 1 | A→C | 1 |
| Thoracic | A | 7 | A→A | 5 | |||
| A→C | 2 |
SCI : spinal cord injury, Tx. : treatment, AIS : American Spinal Injury Association Impairment Scale, N : number of patients, NSPC : neural stem/progenitor cell, SC : Schwann cell, BM : bone marrow, MSC : mesenchymal stem cell, MNC : mononuclear cell, MCP : mononuclear cell preparation, GM-CSF : granulocyte-macrophage colony-stimulating factor