Table 2.
Clinical trials of stem cell transplantation in the chronic phase of SCI
| Study | Stem cell type | Tx. time from SCI | SCI site | PreTx. AIS | N | PostTx. AIS | N |
|---|---|---|---|---|---|---|---|
| Zhu et al. [67] (2016) | UCB-MNCs | 8.8±6.2 (1.6–20.0) years | Cervical | A | 8 | A→A | 7 |
| A→B | 1 | ||||||
| C | 1 | C→C | 1 | ||||
| Thoracic | A | 19 | A→A | 14 | |||
| A→B | 2 | ||||||
| A→C | 3 | ||||||
| Vaquero et al. [59] (2016) | BM-MSCs | 13.9±9.4 (3.2–26.8) years | Thoracic | A | 12 | A→A | 8 |
| A→B | 3 | ||||||
| A→C | 1 | ||||||
| Oh et al. [37] (2016) | BM-MSCs | 5.2±2.8 (2.0–15.1) years | Cervical | A | 1 | A→A | 1 |
| B | 15 | B→B | 15 | ||||
| Al-Zoubi et al. [1] (2014) | Autologous, purified CD34+ and CD133+ stem cells | 1.7±0.8 (1.0–4.0) years | Thoracic | A | 19 | A→A | 10 |
| A→B | 7 | ||||||
| A→C | 2 | ||||||
| Mendonça et al. [34] (2014) | BM-MSCs | 5.1±4.1 (1.5–15.0) years | Thoracic | A | 14 | A→A | 5 |
| A→B | 6 | ||||||
| A→C | 1 | ||||||
| Kishk et al. [26] (2010) | BM-MSCs | 3.6±2.5 years | Cervical, thoracic | A | 40 | A→A | 28 |
| A→B | 11 | ||||||
| A→C | 1 | ||||||
| Thoracic | C | 3 | C→C | 3 | |||
| Deda et al. [8] (2008) | BM MCP | 5.1±5.0 (2–17) years | Cervical, thoracic | A | 9 | A→B | 2 |
| Saberi et al. [44] (2008) | SCs | 3.9±1.7 (2.3–6.7) years | Thoracic | A | 2 | A→A | 2 |
| C | 2 | C→C | 1 | ||||
| C→D | 1 |
SCI : spinal cord injury, Tx. : treatment, AIS : American Spinal Injury Association Impairment Scale, N : number of patients, UCB : umbilical cord blood, MNC : mononuclear cell, BM : bone marrow, MSC : mesenchymal stem cell, MCP : mononuclear cell preparation, SC : Schwann cell