Table 3.
Clinical trials of stem cell transplantation in the mixed phase of SCI
| Study | Stem cell type | Tx. time from SCI | SCI site | PreTx. AIS | N | PostTx. AIS | N |
|---|---|---|---|---|---|---|---|
| Hur et al. [19] (2016) | AD-MSCs | 17.4±6.2 (12–28) months | Cervical | A | 2 | A→A | 2 |
| D | 1 | D→D | 1 | ||||
| Thoracic | A | 5 | A→A | 5 | |||
| Lumbar | A | 1 | A→A | 1 | |||
| 7.0±3.3 (3–11) months | Cervical | A | 3 | A→A | 3 | ||
| B | 1 | B→B | 1 | ||||
| Thoracic | A | 1 | A→A | 1 | |||
| Bhanot et al. [4] (2011) | BM-MSCs | 46.3±36.7 (18–132) months | Cervical | A | 4 | A→A | 4 |
| Thoracic | A | 7 | A→A | 6 | |||
| A→B | 1 | ||||||
| 6.8±2.7 (3–10) months | Cervical | A | 2 | A→A | 2 | ||
| Thoracic | A | 4 | A→A | 4 | |||
| Pal et al. [39] (2009) | BM-MSCs | >6 months | Thoracic | A | 9 | A→A | 9 |
| C | 1 | C→C | 1 | ||||
| <6 months | Cervical | A | 6 | A→A | 2 | ||
| C | 1 | C→C | 1 | ||||
| Thoracic | A | 9 | A→A | 9 | |||
| C | 4 | C→C | 3 | ||||
| Geffner et al. [14] (2008) | BM-MCP | 10.2±6.7 (5.8–21.8) years | Thoracic | A | 1 | A→C | 1 |
| B | 1 | B→C | 1 | ||||
| C | 2 | C→C | 1 | ||||
| C→D | 1 | ||||||
| 5 days to 7 months | Thoracic | A | 4 | A→A | 1 | ||
| A→C | 3 | ||||||
| Yoon et al. [64] (2007) | BM-MNCs | <2 weeks | Cervical, thoracic | A | 17 | A→A | 12 |
| A→B or A→C | 5 | ||||||
| 2–8 weeks | Cervical, thoracic | A | 6 | A→A | 4 | ||
| A→B or A→C | 2 | ||||||
| >8 weeks | Cervical, thoracic | A | 12 | A→A | 12 | ||
| Syková et al. [51] (2006) | BM MCP | 18.0±2.9 (15–22) months | Cervical | B | 1 | B→B | 1 |
| C | 1 | C→C | 1 | ||||
| Thoracic | A | 1 | A→A | 1 | |||
| 10 days to 9 months | Cervical | A | 7 | A→A | 6 | ||
| A→B | 1 | ||||||
| B | 3 | B→B | 2 | ||||
| B→B | 1 | ||||||
| Thoracic | A | 7 | A→A | 7 | |||
| Lima et al. [29] (2006) | OECs | 44.4±18.0 (30–78) months | Cervical | A | 2 | A→A | 1 |
| A→C | 1 | ||||||
| Thoracic | A | 3 | A→A | 3 | |||
| 6 months | Cervical | A | 1 | A→A | 1 | ||
| Thoracic | A | 1 | A→C | 1 |
SCI : spinal cord injury, Tx. : treatment, AIS : American Spinal Injury Association Impairment Scale, N : number of patients, AD : adipose tissue-derived, MSC : mesenchymal stem cell, BM : bone marrow, MCP : mononuclear cell preparation, MNC : mononuclear cell, OEC : olfactory ensheathing cell