Table 2.
Associations between Potential Cognitive Impairment and Severe Chemotherapy Toxicity
| Univariate Analysis | Adjusted Analysis* | |||||||
|---|---|---|---|---|---|---|---|---|
| Severe Chemotherapy Toxicity | OR (95% CI) | p-value | Severe Chemotherapy Toxicity | OR (95% CI) | p-value | |||
| No | Yes | No | Yes | |||||
| Overall | ||||||||
| Cognition | 0.007 | 0.08 | ||||||
| Normal | 222 | 231 | 211 | 222 | ||||
| Potential Impairment | 96 | 154 | 1.54 (1.13–2.11) | 92 | 144 | 1.35 (0.96–1.90) | ||
| By Race/ Ethnicity | ||||||||
| White | ||||||||
| Normal Cognition | 191 | 206 | 183 | 197 | ||||
| Potential Impairment | 80 | 118 | 1.37 (0.97–1.93) | 0.08 | 79 | 111 | 1.24 (0.86–1.80) | 0.25 |
| Non-White | ||||||||
| Normal Cognition | 31 | 25 | 28 | 25 | ||||
| Potential Impairment | 16 | 36 | 2.79 (1.27–6.15) | 0.01 | 13 | 33 | 1.98 (0.76–5.17) | 0.16 |
| By Education Level | ||||||||
| High School Education or Less | ||||||||
| Normal Cognition | 75 | 78 | 72 | 77 | ||||
| Potential Impairment | 36 | 69 | 1.84 (1.10–3.08) | 0.02 | 33 | 64 | 1.87 (1.06–3.29) | 0.03 |
| Greater than High School Education | ||||||||
| Normal Cognition | 146 | 153 | 138 | 145 | ||||
| Potential Impairment | 60 | 85 | 1.35 (0.91–2.02) | 0.14 | 59 | 80 | 1.13 (0.73–1.74) | 0.58 |
Abbreviations: OR = odds ratio; CI = confidence interval
*
Adjusted for CARG Toxicity Risk group (low, middle, high), 34 patients excluded due to missing CARG Toxicity Risk score data