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Small molecules can partially stabilize or non-specifically bind RNA. 2D [13C,1H] aromatic SOFAST-HMQC [39] spectra of free TARUUCG-ES (blue), TARUUCG-ES + 16x small molecule (red), free wtTAR (green), and wtTAR + 8x small molecule (orange) for a. DMA-169 and b. neomycin. Buffer conditions are 15 mM sodium phosphate, 25 mM sodium chloride, 0.1 mM EDTA, 10% D2O at pH 6.4 and 25 °C.
