Table 1.
Patient socio-demographic and Cancer and Aging Research Group chemotherapy toxicity characteristics; overall and by the level of social support
| Characteristics | Overall (N=498) | By the level of social support |
||
|---|---|---|---|---|
| Poor (≤ 75, N=130) | Good (> 75, N=368) | P value* | ||
| Age (years) | 0.02† | |||
| Mean (SD) | 73.1 (6.2) | 74.2 (6.4) | 72.7 (6.1) | |
| Median (range) | 72.0 (65–91) | 73.5 (65–91) | 72.0 (65–89) | |
| % for >72 years | 54.0 | 63.1 | 50.8 | |
| Sex, % | 0.55 | |||
| Female | 56.2 | 58.5 | 55.4 | |
| Male | 43.8 | 41.5 | 44.6 | |
| Race/ethnicity, % | 0.05 | |||
| White | 85.1 | 83.9 | 85.6 | |
| Black | 8.4 | 13.1 | 6.8 | |
| Asian | 5.2 | 2.3 | 6.3 | |
| Other | 1.2 | 0.8 | 1.4 | |
| Education level, % | 0.41 | |||
| Less than high school | 3.4 | 4.6 | 3.0 | |
| High school graduate | 35.1 | 30.0 | 37.0 | |
| Associate/bachelor’s degree | 40.4 | 44.6 | 38.9 | |
| Advanced degree | 20.9 | 20.8 | 20.9 | |
| Missing‡ | 0.2 | 0 | 0.3 | |
| Marital status, % | <0.001 | |||
| Married | 61.2 | 46.2 | 66.6 | |
| Widowed | 22.5 | 30.8 | 19.6 | |
| Single | 3.2 | 3.1 | 3.3 | |
| Separated, divorced | 13.1 | 20.0 | 10.6 | |
| Employment status, % | 0.05 | |||
| Full or part time | 16.7 | 11.5 | 18.5 | |
| Retired, homemaker, unemployed | 78.9 | 81.5 | 78.0 | |
| Disable, medical leave | 4.2 | 6.9 | 3.3 | |
| Missing‡ | 0.2 | 0.0 | 0.3 | |
| Household composition | <0.001 | |||
| Lives alone | 21.1 | 32.3 | 17.1 | |
| Lives with spouse, partner, or child | 78.3 | 66.2 | 82.6 | |
| Missing‡ | 0.6 | 1.5 | 0.3 | |
| BMI§, kg/m2 | 0.24† | |||
| Mean (SD) | 26.0 (4.6) | 25.6 (4.8) | 26.1 (4.5) | |
| Median (range) | 24.8 (16.7–51.6) | 23.7 (16.9–51.6) | 25.2 (16.7–49.4) | |
| Cancer type, % | 0.67 | |||
| Breast | 11.5 | 11.5 | 11.4 | |
| Lung | 28.7 | 32.3 | 27.5 | |
| Gastrointestinal | 26.7 | 25.4 | 27.2 | |
| Gynecological | 17.5 | 19.2 | 16.9 | |
| Genitourinary | 10.0 | 7.7 | 10.9 | |
| Other | 5.6 | 3.9 | 6.3 | |
| Cancer Stage, % | 0.79 | |||
| I | 4.6 | 3.1 | 5.2 | |
| II | 11.7 | 12.3 | 11.4 | |
| III | 21.9 | 23.1 | 21.5 | |
| Limited | 0.4 | 0.8 | 0.3 | |
| IV/extensive | 61.5 | 60.8 | 61.7 | |
| Number of Comorbidity | 0.63† | |||
| Mean (SD) | 2.4 (1.7) | 2.5 (1.6) | 2.4 (1.7) | |
| Median (range) | 2.0 (0–9) | 2 (0–7) | 2 (0–9) | |
| No. of Chemotherapy Agents, % | 0.94 | |||
| Monochemotherapy | 29.7 | 30.0 | 29.6 | |
| Polychemotherapy | 70.3 | 70.0 | 70.4 | |
| Standard dose, % | 0.11 | |||
| Reduced | 24.1 | 29.2 | 22.3 | |
| Standard | 75.9 | 70.8 | 77.7 | |
| Hemoglobin (g/dl), % | 0.42 | |||
| ≥10 (female), ≥11 (male) | 85.9 | 86.2 | 85.9 | |
| <10 (female), <11 (male) | 12.3 | 10.0 | 13.0 | |
| Missing‡ | 1.8 | 3.9 | 1.1 | |
| Creatinine clearance (ml/min), % | 0.54 | |||
| ≥34 | 88.0 | 85.4 | 88.9 | |
| <34 | 8.8 | 10.0 | 8.4 | |
| Missing‡ | 3.2 | 4.6 | 2.7 | |
| Hearing, % | 0.73 | |||
| Excellent/good | 74.1 | 72.3 | 74.7 | |
| Fair/poor/deaf | 24.5 | 25.4 | 24.2 | |
| Missing‡ | 1.4 | 2.3 | 1.1 | |
| No. of falls in last 6 months, % | 0.15 | |||
| 0 | 81.5 | 77.7 | 82.9 | |
| ≥1 | 18.1 | 22.3 | 16.6 | |
| Missing‡ | 0.4 | 0 | 0.5 | |
| Taking medicine with some help/unable, % | 0.28 | |||
| No | 92.2 | 90.0 | 92.9 | |
| Yes | 7.8 | 10.0 | 7.1 | |
| Walking one block, somewhat limited/limited a lot, % | 0.03 | |||
| No | 77.1 | 70.0 | 79.6 | |
| Yes | 21.9 | 28.5 | 19.6 | |
| Missing‡ | 1.0 | 1.5 | 0.8 | |
| Decreased social activity because of physical/emotional health, limited at least sometimes, % | <0.001 | |||
| No | 55.6 | 40.0 | 61.1 | |
| Yes | 43.6 | 57.7 | 38.6 | |
| Missing‡ | 0.8 | 2.3 | 0.3 | |
| CARG Toxicity Risk Group | 0.20 | |||
| Low | 25.5 | 19.2 | 27.7 | |
| Medium | 45.6 | 44.6 | 45.9 | |
| High | 21.7 | 24.6 | 20.7 | |
| Missing‡ | 7.3 | 11.5 | 5.7 | |
*
Ascertained from Chi-square test, except where otherwise noted.
†
Ascertained from two sample t test.
‡
Missing categories were not included in statistical tests.
§
Two patients without BMI information.
Abbreviation: SD = standard deviation, BMI = body mass index