Table 2.
Summary of neuropsychological testing data obtained using the NIH Toolbox Cognition Battery (mean scores [SD]).
| NIH Toolbox Score | Time Point 1 | Time Point 2 | Change Over time | ||||
|---|---|---|---|---|---|---|---|
| Chemotherapy Group* | Healthy Control Group | Chemotherapy Group | Healthy Control Group | Chemotherapy Group | Healthy Control Group | pb | |
| Crystallized cognition composite | 111.04 (15.38) | 107.45 (15.61) | 111.64 (12.77) | 107.29 (18.61) | −0.12 (7.65) | −0.16 (6.38) | 0.9887 |
| Fluid cognition composite | 100.06 (13.6) | 99.79 (9.71) | 100.22 (13.54) | 105.58 (15.09) | 0.57 (10.97) | 5.79 (11.89) | 0.2083 |
| Total cognition composite | 105.39 (18.14) | 101.93 (14.82) | 105.09 (14.83) | 105.65 (20.01) | −0.71 (9.8) | 3.72 (8.7) | 0.1924 |
| Dimensional change card sort | 100.89 (11.24) | 102.68 (12.47) | 101.02 (6.96) | 108.27 (8.84) | 0.73 (8.06) | 5.59 (12.13) | 0.1847 |
| Flanker Inhibitory control and attention | 95.17 (10.62) | 98.32 (9.16) | 92.64 (8.66) | 100.23 (5.69) | −2.8 (11.67) | 1.91 (7.46) | 0.1992 |
| List sorting working memory | 102.21 (15.81) | 100.9 (15.83) | 106.94 (10.3) | 105.01 (17) | 5.25 (9.66)a | 4.11 (14.07) | 0.7869 |
| Oral reading recognition | 112.16 (11.38) | 103.09 (12.31) | 109.13 (12.1) | 103.84 (14.07) | −3.72 (6.23)a | 0.75 (6.27) | 0.0534 |
| Pattern comparison processing speed | 92.46 (14.6) | 97.32 (13.44) | 93.16 (16.86) | 95.4 (16.45) | 0.36 (14.14) | −1.92 (15.09) | 0.6637 |
| Picture sequence memory test | 111.23 (19.53) | 102.49 (16.32) | 108.44 (20.27) | 110.3 (25.05) | −2.25 (11.52) | 7.81 (20.83) | 0.092 |
| Picture vocabulary | 106.68 (14.94) | 109.7 (13.97) | 110.5 (10.9) | 107.71 (16.55) | 3.37 (9.6) | −1.99 (6.09) | 0.0784 |
a
p<0.05 comparing the scores from Time point 1 to Time point 2 in the chemotherapy group.
b
p-values comparing changes over time (Time Point 1 to Time Point 2) between the chemotherapy group and the healthy control group.
*
18 chemotherapy patient: 1 patient without Time Point 1 neuropsychological testing data.