Table 3.
Diffusion tensor imaging parameters for the white matter skeleton and selected regions for region of interest analysis. Values indicate the mean change in each parameter from time point 1 to time point 2.
| Chemotherapy Group (n=19) | Healthy Control Group (n=14) | ||
|---|---|---|---|
| Mean change (SD) | Mean change (SD) | ||
| Skeleton | FA | −0.007 (0.012) | −0.016 (0.010) |
| AD (×10−3 mm2/s) | 0.013 (0.023) | −0.010 (0.017) | |
| MD (×10−3 mm2/s) | 0.013 (0.014) | 0.003 (0.013) | |
| RD (×10−3 mm2/s) | 0.014 (0.012) | 0.010 (0.013) | |
| Genu of corpus callosum | FA | −0.006 (0.015) | −0.008 (0.016) |
| AD (×10−3 mm2/s) | 0.029 (0.052) | 0.002 (0.021) | |
| MD (×10−3 mm2/s) | 0.029 (0.035)a | 0.008 (0.014) | |
| RD (×10−3 mm2/s) | 0.028 (0.030)b | 0.011 (0.017) | |
| Splenium of corpus callosum | FA | −0.002 (0.011) | −0.009 (0.010) |
| AD (×10−3 mm2/s) | 0.028 (0.043) | 0.004 (0.015) | |
| MD (×10−3 mm2/s) | 0.017 (0.024) | 0.010 (0.010) | |
| RD (×10−3 mm2/s) | 0.011 (0.018) | 0.011 (0.013) | |
| Superior longitudinal fasciculus (Left) | FA | 0.003 (0.015) | −0.006 (0.009) |
| AD (×10−3 mm2/s)c | 0.016 (0.027) | −0.011 (0.025) | |
| MD (×10−3 mm2/s) | 0.008 (0.013) | −0.005 (0.016) | |
| RD (×10−3 mm2/s) | 0.004 (0.011) | −0.002 (0.014) | |
| Superior longitudinal fasciculus (Right) | FA | 0.001 (0.018) | −0.013 (0.017) |
| AD (×10−3 mm2/s) | 0.015 (0.028) | −0.007 (0.014) | |
| MD (×10−3 mm2/s) | 0.009 (0.017) | 0.004 (0.007) | |
| RD (×10−3 mm2/s) | 0.007 (0.017) | 0.009 (0.011) |
FA: fractional anisotropy, MD: mean diffusivity, RD: radial diffusivity, AD: axial diffusivity
a, b
indicates significant within-group changes from time point 1 to time point 2 in the chemotherapy group (p<0.01 after Bonferroni correction).
c
indicates significant between-group difference when comparing the changes from time point 1 to time point 2 in the chemotherapy group to the changes in the healthy control group (p<0.05).