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. 2020 Feb 26;7:88. doi: 10.3389/fvets.2020.00088

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Copyright © 2020 Gan, Mao, Jiang, Zhang, Liu, Cao, Wang, Wang, Sun, Huang and Ye.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Virulence analysis of L. ivanovii subsp. ivanovii strains in mouse model. Change in body weight (A) and bacterial loads in the liver (B), spleen (C), lung (D), kidney (E), and intestine (F) were recorded for 7 days. Bars represent the mean of five replicates mean ± SD. Histopathologic analysis of organs in 4 dpi were shown in (G–Z). (G–V) were captured under the 40x microscope, and (W–Z) were captured under the 20x microscope. The green arrows denote the pathologic injuries such as neutrophil infiltration, hemorrhage, alveolar septum widened and granuloma.