FIGURE 7.

The QSI inhibitor delivered in nanoparticles (ALG_QSI) reduced biofilm formation by P. aeruginosa alone and in polymicrobial biofilms. HaCat monolayers were inoculated with S. aureus (40 h growth) and P. aeruginosa (20 h growth) alone or together with commensals (as outlined in Figure 1) in the presence or absence of ALG_QSI nanoparticles. The biomass was quantified and plotted. SE: S. epidermidis; ML: M. luteus; SA: S. aureus; PA: P. aeruginosa. Bold font indicates the bacterial species quantified. ^∗p-value < 0.05. Not all the statistically significant values have been marked. Images of the biofilms and HaCat monolayer are shown in Supplementary Figure S1, and average thickness and surface area are shown in Supplementary Figure S3.