Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 3;10:3890. doi: 10.1038/s41598-020-60824-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Binding of a cocaine-HCl molecule to the binding site of: (a,b) Wild type (WT) mosquito- AgamOBP1, and (c,d) AgamOBP1_mutant S82P. In (a) cartoon representation of the X-Ray structure and (b) hydrophobicity surface representation, the cocaine-HCl molecule shows does not fit into the WT AgamOBP1 binding pocket, but in (c), cartoon representation, (d) hydrophobicity surface representation, after substitution of residue number 82 Serine (S) with Proline (P) to produce the mutant S82P, the cocaine-HCl molecule can now fit into the binding pocket. (e) Structural superposition of (b) and (d), where cocaine-HCl molecule in (b) is shown in light pink, while cocaine-HCl in (d) is shown in green. Residue S82 from (b) and residue P82 from (d) are labelled.