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. 2020 Mar 3;10:3902. doi: 10.1038/s41598-020-60604-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PRK1 and PRK2 interact with centriole associated components and structures and localise to the transition zone of cilia. (A) Centriole associated proteins stated (thebiogrid.org) to interact with PRK1 or PRK2. (B) Immunofluorescence images of centriolar structures (centrosomes and cilia). (C–E) Immunofluorescence images of pPRK1 and pPRK2 (pPRK1/2) at the base of cilia with various other cilia associated markers. Line traces along the cilium are shown to demonstrate localization to the transition zone. (F) Immunofluorescence image of a NIH3T3 cell exogenously expressing PRK2 fused to GFP (PRK2:GFP). Scale bar represents 2 µm. (G) Western blot analysis of lysate from cells treated with non-targeting (NT) or PRK1 and PRK2 (PRK1 + PRK2) siRNA. Unless stated otherwise, n ≥ 3.