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. 2020 Mar 3;10:3924. doi: 10.1038/s41598-020-60177-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Range of bistability in the mPTP opening model. In blue: the system is bistable; in orange-coloured: the system has one stable steady-state; in yellow: the system oscillates at high $P T P$ values. Sensitivity analysis was performed by individually varying seven different parameters from 10 to 1000 % of their default values. See Fig. S3 for bistability conditions and notes on oscillatory behaviour.