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. 2020 Mar 3;11(3):166. doi: 10.1038/s41419-020-2363-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Expression of Alcα mRNA in an eye of 5-month-old wild-type mice was detected by in situ hybridization (ISH). The magnified image in the boxed area of the left side image is shown on the right side. Alcα mRNA is readily detected in ganglion cells, cells in inner nuclear layer, and photoreceptors’ inner segment. GCL: ganglion cell layer, INL: inner nuclear layer, ONL: outer nuclear layer. Scale bar, 500 μm. b Expression of Alcα protein in an eye of 5-month-old wild-type (WT) and Alcα-deficient (KO) mouse was detected by immunohistochemistry (IHC). Alcα protein is readily detected in ganglion cells, photoreceptors’ inner segment, and outer peripheral layer. Alcα protein is not detected in the eye of Alcα-deficient mouse. Co-stained images with DAPI are shown on the right sides. GCL: ganglion cell layer, INL: inner nuclear layer, ONL: outer nuclear layer. Scale bar, 50 μm. c Expression of Alcα protein in a retina of 2-month-old wild-type (WT) and Alcα-deficient (KO) mouse was detected by western blotting. Alcα protein is not detected in the retinal lysate (1 μg) of Alcα-deficient (KO) mouse.