Table 1.

A summary of key published anticoccidial vaccination studies.

Species (No. papers)	Formulation	Vaccine challenge study details		Outcome parameters measured
		Breed L = layer B = Broiler	Challenge dose (oocyst) L = low, h = high	Oocyst output	Lesion score	Body weight gain	Feed conversion ratio	qPCR parasite replication	Histo-pathology	Survival rate	Anti-coccidial index (ACI)	Serum antibodies	Other immune parameters
E. acervulina (22)	DNA 5/22	L 10/22	L 2/22 (5,000)	16	13	18	1	0	0	3	5	10	10
	rProtein 12/22	B 12/22	H 20/22 (<5000)
	Other 5/22
E. brunetti (2)	DNA 1/2	L 0/2	L 0/2	2	2	2	0	0	0	0	2	2	2
	rProtein 2/2	B 2/2	H 2/2 (100,000)
	Other 0/2
E. maxima (14)	DNA 3/14	L 3/14	L 5/14 (<1000)	12	6	11	1	0	1	4	3	10	9
	rProtein 7/14	B 5/14	H 9/14 (>1000)
	Other 4/14	NS 3/14
		Other 3/14
E. mitis (1)	DNA 0/1	L 1/1	L 0/1	1	0	1	0	0	0	0	0	1	1
	rProtein 1/1	B 0/1	H 1/1 (100,000)
	Other 0/1
E. tenella (43)	DNA 13/43	L 16/43	L 2/43 (<1,000)	40	29	38	1	1	1	10	14	28	18
	rProtein 19/43	B 19/43	H 40/43 (>1,000)
	Other 11/43	NS 2/43	NS 1/43
		Other 6/43
Multiple (8)	DNA 4/8	L 2/8	L 1/8 (<10,000)	6	5	5	0	0	0	2	4	4	3
	rProtein 5/8	B 5/8	H 7/8 (>10,000)
	Other 0/8	NS 1/8

For further details see Supplementary Table 1. NS, not specified.