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. 2020 Mar 3;10:3906. doi: 10.1038/s41598-020-60935-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HIF1 is essential for granulosa cell function. Expression of HIF1A is induced by FSH, IGF1 and low oxygen levels in bovine granulosa cells. HIF1 may regulate steroidogenesis, cell proliferation, angiogenesis and inflammation processes in developing ovarian follicles.