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. 2020 Mar 3;10:3951. doi: 10.1038/s41598-020-59043-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ethanol induced gene expression changes during zygotic genome activation. (A) Venn diagram shows overlapping of ethanol dysregulated genes identified in the Affymetrix GeneChip microarray analysis of control and ethanol treated embryos at 4.5 hpf with potential Sox2 targets and the genes differentially expressed in quadruple knockdown of SoxB1 factors, which includes Sox2 (Soxb1 QKD targets). (B) Twenty five of the ethanol-dysregulated transcription factors showing the enrichment of their targets in our ethanol-dysregulated gene set. (C) Transcription factor-target gene network visualizing using cytoscape shows interactions among the transcription factors (gold circles) and their target gene (blue circles) in our dataset. Ethanol dysregulated targets of Sox2 are co-shared by other dysregulated transcription factors.