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. 2020 Feb 26;11:37. doi: 10.3389/fgene.2020.00037

Figure 1.

Figure 1

Ryanodine receptor (RyR) variants confer a malignant hyperthermia (MH)-related phenotype of hypersensitivity to halothane. Thrashing rate in S medium, in body bends per minute, for RyR variant strains, labelled by the human variant they correspond to, in the absence of (A) and presence of (B) 5 mM halothane / 4% DMSO. 25 individual young adults were examined per strain. Boxes indicate the median and interquartile range, with whiskers to the 10–90 percentile, outliers as dots, and + to indicate the mean. Significance is between variant strains and the N2 wild type, apart from where indicated to the CB540 unc-68(e540) null mutant. *P < 0.05, ** P < 0.005, n.s, not significant (one-way ANOVA, with Tukey’s multiple comparison test). Colouring corresponds to variant location in the protein. Yellow/orange variants are located within the N-terminal domain (NTD), green in the helical domain (HD), and blue in the transmembrane domain (TMD). Gray represents wild type and lilac the null mutant.