Figure 2.

Locomotion is differentially affected across the lifespan by ryanodine receptor (RyR) variants. Thrashing rate in S medium, in body bends per minute, for RyR variant strains, labelled by the human variant they correspond to, along with the N2 wild type and the CB540 unc-68(e540) null mutant. Comparisons are between young adult (YA) and old adult (OA) in the absence (A) and presence (B) of 5 mM halothane or between strains as L1s in the absence of halothane (C). 25 individuals were examined per strain. Boxes indicate the median and interquartile range, with whiskers to the 10–90 percentile, outliers as dots, and + to indicate the mean. Significance is between ages of each variant strain (A, B) or to the wild type (C). *P < 0.05, **P < 0.005, n.s, not significant [one-way ANOVA, with Sidak’s multiple comparison test (A, B), and Tukey’s multiple comparison test (C)].