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. 2020 Feb 26;11:37. doi: 10.3389/fgene.2020.00037

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Copyright © 2020 Graham, Shaw and Hope

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ryanodine receptor (RyR) variants alter time to paralysis in 1 mM aldicarb. Kaplan-Meier survival curves representing the percentage of individuals still moving with time in 1 mM aldicarb. Data for the RyR variant strains, labelled by the human variant they correspond to, along with the N2 wild type and the CB540 unc-68(e540) null mutant are distributed across two graphs for clarity. Comparison to the wild type, and of the hR4861H variant strain to the unc-68 null mutant (square bracket), to assess if curves were significantly different, employed the Gehan-Breslow-Wilcoxon test; *P < 0.05, *P < 0.005, n.s, not significant.