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. 2020 Feb 26;11:37. doi: 10.3389/fgene.2020.00037

Figure 6.

Figure 6

Locomotion effects in heterozygous ryanodine receptor (RyR) variant individuals. Thrashing rate in S medium, in body bends per minute, for 25 individuals, in the absence of (A) and presence of (B) 5 mM halothane. Those expressing RyR variants are identified by the human variant they correspond to, and were either heterozygous (HET), with the modified unc-68 over a wild type unc-68 introduced by mating, or homozygous (HOM) for the modified unc-68. Corresponding N2 wild type and unc-68(e540) null mutant individuals were generated and assayed in the same way, in parallel, for direct comparison, although the wild type “heterozygotes” (“HET”) and “homozygotes” (“HOM”) are fully wild type for unc-68. Boxes indicate the median and interquartile range, with whiskers to the 10–90 percentile, outliers as dots, and + to indicate the mean. Significance is between heterozygotes and homozygotes. *P < 0.05, **P < 0.005, n.s, not significant (one-way ANOVA, with Sidak’s multiple comparison test).