Table 1.
ASD Females | ASD Males | NT Females | NT Males | Females ASD vs. NT | Males ASD vs. NT | ASD Female vs. Male | NT Female vs. Male | |
---|---|---|---|---|---|---|---|---|
Age | 13.84 | 13.50 | 13.49 | 13.17 | 0.59 | 0.50 | 0.53 | 0.60 |
Full IQ | 97.91 | 105.24 | 112.97 | 106.26 | 0.001b | 0.72 | 0.08 | 0.03a |
Nonverbal IQ | 99.53 | 105.65 | 110.82 | 105.32 | 0.009b | 0.92 | 0.12 | 0.11 |
Verbal IQ | 101.16 | 103.73 | 111.18 | 107.09 | 0.018a | 0.23 | 0.50 | 0.19 |
ADOS social | 7.97 | 9.70 | – | – | – | – | 0.05a | – |
ADOS repetitive behavior | 2.06 | 2.29 | – | – | – | – | 0.57 | – |
ADOS severity score | 6.13 | 7.02 | – | – | – | – | 0.10 | – |
ADI social | 19.09 | 20.11 | – | – | – | – | 0.41 | – |
ADI Communication | 15.77 | 16.30 | – | – | – | – | 0.64 | – |
ADI repetitive behavior | 6.00 | 6.78 | – | – | – | – | 0.21 | – |
Mean relative motion | 0.12 | 0.08 | 0.09 | 0.08 | 0.16 | 0.27 | 0.02a | 0.10 |
Mean volumes scrubbed | 14.97 | 2.81 | 8.58 | 2.97 | 0.21 | 0.89 | 0.003b | 0.07 |
Mean OXTR risk variants | 3.44 | 3.30 | 3.45 | 3.12 | 0.94 | 0.47 | 0.58 | 0.19 |
Subjects with ≥1 risk allele | ||||||||
rs1042778 | 28 | 30 | 27 | 23 | 0.53 | 0.19 | 0.47 | 0.18 |
rs2254298 | 6 | 7 | 8 | 9 | 0.59 | 0.45 | 0.99 | 0.83 |
rs53576 | 21 | 20 | 21 | 12 | 0.87 | 0.11 | 0.33 | 0.02a |
rs237887 | 28 | 27 | 25 | 29 | 0.22 | 0.20 | 0.14 | 0.32 |
Self-reported ethnicity | ||||||||
Asian | 2 | 2 | 3 | 3 | 0.67 | 0.57 | 0.88 | 0.97 |
Black/African American | 0 | 2 | 3 | 6 | 0.08 | 0.10 | 0.18 | 0.31 |
Other/Mixed | 4 | 4 | 5 | 2 | 0.76 | 0.46 | 0.83 | 0.22 |
White | 26 | 25 | 22 | 19 | 0.18 | 0.31 | 0.20 | 0.37 |
Mean values and p-values derived from two-tailed independent samples t-tests or chi-squared tests. ap < 0.05; bp < 0.01.
ASD autism spectrum disorder, NT neurotypical, IQ intelligence quotient, ADOS Autism diagnostic observation schedule, ADI Autism Diagnostic interview, OXTR oxytocin receptor gene.