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. 2020 Jan 30;63(4):744–756. doi: 10.1007/s00125-019-05083-6

Table 2.

 Individual edge effect estimates for the TC and TC-PA structural equation models

Outcome node/parent node (edge) Cohort 1
(no diabetes/prediabetes)
Cohort 2 (diabetes)
β β SE p value β β SE p value
TC model
 OGIS/
  LF (is1) −0.23 0.04 <0.001 −0.11 0.06 0.09
 LF/
  FI (lf1) 0.41 0.04 <0.001 0.44 0.05 <0.001
 FI/
  FG (fi1) −0.06 0.03 0.05 −0.25 0.06 <0.001
  IS (fi2) −0.70 0.03 <0.001 −0.70 0.06 <0.001
 FG/
  IS (fg1) −0.67 0.03 <0.001 −0.73 0.03 <0.001
  GS (fg2) −0.26 0.03 <0.001 −0.31 0.03 <0.001
 TG/
  IS (tg1) −0.31 0.03 <0.001 −0.34 0.05 <0.001
  LF (tg2) 0.22 0.03 <0.001 0.13 0.05 0.006
 PF/
  TG (pf1) 0.14 0.03 <0.001 0.01 0.05 0.886
 GS/
  PF (gs1) −0.05 0.04 0.185 <0.01 0.05 0.967
  IS (gs2) −0.21 0.03 <0.001 0.02 0.05 0.63
 PG/
  IS (pg1) −0.58 0.03 <0.001 −0.67 0.03 <0.001
  GS (pg2) −0.17 0.03 <0.001 −0.38 0.03 <0.001
TC-PA model
 IS/
  PA (is2) 0.30 0.04 <0.001 0.21 0.05 <0.001
  LF (is1) −0.20 0.04 <0.001 −0.12 0.07 0.065
 LF/
  PA (lf2) −0.04 0.04 0.234 −0.04 0.05 0.447
  FI (lf1) 0.41 0.04 <0.001 0.44 0.05 <0.001
 FI/
  PA (fi3) −0.12 0.03 <0.001 −0.16 0.05 0.001
  FG (fi1) −0.04 0.03 0.265 −0.23 0.07 <0.001
  IS (fi2) −0.64 0.04 <0.001 −0.64 0.07 <0.001
 FG/
  PA (fg3) 0.11 0.03 0.001 0.06 0.03 0.061
  IS (fg1) −0.70 0.03 <0.001 −0.73 0.03 <0.001
  GS (fg2) −0.26 0.03 <0.001 −0.28 0.03 <0.001
 TG/
  PA (tg3) −0.13 0.04 <0.001 −0.13 0.05 0.012
  OGIS (tg1) −0.26 0.04 <0.001 −0.30 0.05 <0.001
  LF (tg2) 0.22 0.04 <0.001 0.16 0.05 0.002
 PF/
  PA (pf2) −0.06 0.03 0.067 −0.01 0.06 0.809
  TG (pf1) 0.14 0.03 <0.001 −0.01 0.05 0.819
 GS/
  PA (gs3) −0.05 0.04 0.212 −0.12 0.06 0.032
  PF (gs1) −0.05 0.05 0.314 0.01 0.05 0.835
  IS (gs2) −0.18 0.04 <0.001 0.02 0.05 0.696
 PG/
  PA (pg3) −0.04 0.03 0.194 −0.05 0.04 0.162
  IS (pg1) −0.56 0.03 <0.001 −0.67 0.03 <0.001
  GS (pg2) −0.17 0.03 <0.001 −0.39 0.03 <0.001

All continuous variables were normally transformed and adjusted for age, sex, metformin treatment (cohort 2), study centre, total energy intake and carbohydrate, fat and protein intake

See Text box for node and edge abbreviations