Table 2.

Multivariable linear regression analyses demonstrating associations of thyroid function variables with cigarette smoking adjusted for age and sex in 5766 participants of the PREVEND study

	Model 1: TSH		Model 2: FT4		Model 3: FT3
	β	P-value	β	P-value	β	P-value
Age	−0.021	<0.001	−0.028	0.036	−0.167	<0.001
Sex (M vs. F)	−0.075	<0.001	0.117	<0.001	0.286	<0.001
Smoking
Never (reference) former	−0.037	0.020	0.026	0.10	−0.008	0.59
Current  ≤20 cigarettes per day	−0.140	<0.001	0.043	0.006	0.055	<0.001
Current  >20 cigarettes per day	−0.083	<0.001	0.018	0.18	0.058	<0.001

Smoking status is categorized as never (reference category); former and current, which is divided in <20 and ≥20 cigarettes per day. β: standardized regression coefficients

F female, FT4 free thyroxine, FT3 free triiodothyronine, M male, TSH thyroid stimulating hormone. TSH is log_e transformed