Table 2.
Main findings of experimental data on IL-17C and IL-17RE.
| Disease model | Mice used | Main phenotype of investigated group | References | |
|---|---|---|---|---|
| Experimental autoimmune encephalitis (EAE) | Il17c−/− | Less clinical manifestation, lower mortality | (40) | |
| Il17re overexpressing CD4+ T cells adoptively transferred to wildtype C57Bl/6 | Increase in EAE symptoms | |||
| Nephrotoxic Nephritis (NTN) |
Il17c−/− Il17re−/− |
Reduced functional and morphological kidney damage, less renal Th17 infiltration | (24) | |
| Pristane-induced lupus nephritis | Il17c−/− | Reduced functional and morphological kidney damage | (24) | |
| Psoriasis | Imiquimod-induced |
Il17c−/− Il17re−/− |
Less severe course of the disease | (19, 49) |
| Il-17c- induced | Il17c overexpression in keratinocytes of wildtype C57Bl/6 | Spontaneous development of psoriasiform skin lesions | (48) | |
| IL-23-induced | BALB/c | Reduced ear swelling and acanthosis under anti-IL-17C treatment | (50) | |
| Con-A-induced autoimmune hepatitis |
Il17c−/− Il17re−/− |
Lesser levels of GOT and GPT, attributed to inhibited NK-cell mediated liver damage | (51) | |
| Il17c−/− | No difference in GOT and GPT levels or hepatic granulocyte infiltration | (52) | ||
| Collagen-induced Arthritis (CIA) |
Il17c overexpressing CD4+ T cells adoptively transferred to DBA1 mice Il17c BM chimeric mice |
Higher arthritis scores than control | (30) | |
| Atopic dermatitis | MC903-induced | BALB/c | Less severe ear swelling under anti-IL-17C treatment | (50) |
| Flaky tail | Flaky tail (Mattma/maFlgft/ft) | Less hair loss and excoriation and ameliorated blepharitis under anti-IL-17C treatment | ||
| Dextrane sulfate sodium (DSS) induced colitis |
Il17c−/− Il17re−/− |
More pronounced body weight loss and colonic shortening due to lesser expression of antibacterial, inflammatory, and tight-junction molecules | (19, 41, 52) | |
| Citrobacter rodentium infection | Il17re−/− | More body weight loss, higher intestinal and splenic weight, higher bacterial burden, higher mortality | (9) | |
| Pseudomonas aeruginosa airway infection | Il17c−/− | Increased survival | (26) | |
| Systemic Candida albicans infection | Il17c−/− | Increased survival and less severe kidney damage | (25) | |
| Systemic, oral and dermal Candidiasis |
Il17c−/− Il17re−/− |
No difference between knockout and wildtype groups | (45) | |
| LPS-induced endotoxin shock | Il17c−/− | Higher resistance to endotoxin-induced shock. | (52) | |
Summary of current data on the IL-17C/RE axis in mouse models.