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. 2020 Feb 26;11:91. doi: 10.3389/fneur.2020.00091

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At least a portion of this work is authored by Katie A. Edwards, Vida Motamedi, Nicole D. Osier, Hyung-Suk Kim, Young-Eun Cho, Chen Lai, Kristine C. Dell, Walter Carr, Peter Walker, Stephen Ahlers, Matthew LoPresti, Angela Yarnell, Anna Tschiffley and Jessica M. Gill on behalf of the U.S. Government and, as regards Katie A. Edwards, Vida Motamedi, Nicole D. Osier, Hyung-Suk Kim, Young-Eun Cho, Chen Lai, Kristine C. Dell, Walter Carr, Peter Walker, Stephen Ahlers, Matthew LoPresti, Angela Yarnell, Anna Tschiffley and Jessica M. Gill and the U.S. Government, is not subject to copyright protection in the United States. Foreign and other copyrights may apply.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Network shows dysregulated cell death and survival pathway following moderate blast. Genes described in the text included: UPF1, UPF3B, ARRB1, ZBTB7B, flt3, HIBCH, RPL6, RPL35, MRPL1, MRPL3, MRPL36, and MRPL50. Red indicates increased measurement; green represents decreased measurement; with increased color saturation representing more extreme measurement in dataset. Solid lines represent direct interactions, non-targeting interactions, or correlations between chemicals, proteins, or RNA. Dotted lines represent indirect interactions. Purple lines denote the commonly found relationship among the two merged networks. Arrowed lines represent activation, causation, expression, localization, membership, modification, molecular cleavage, phosphorylation, protein-DNA interactions, protein-RNA interactions, regulation of binding, transcription. Shapes represent molecule type (double circle, complex/group; square, cytokine; diamond, enzyme; inverted triangle, kinase; circle, other; triangle, phosphatase; oval, transcription regulator; trapezoid, transporter). The network was generated through the use of IPA (QIAGEN Inc., https://www.qiagenbioinformatics.com/products/ingenuity-pathway-analysis).