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. 2020 Feb 26;10:115. doi: 10.3389/fonc.2020.00115

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Copyright © 2020 Yang, Chen, Yu, Lu, Wu, Wang, Ju, Xu, Liu and Zeng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The association between methyltransferase-like 3 (METTL3) upregulation and abnormal m6A levels in gastric cancer (GC). (A) Relative expression pf writers and erasers in the The Cancer Genome Atlas (TCGA) database (normal mucosa = 32, tumor tissue = 375). (B) Total RNA m6A levels in 13 paired gastric carcinoma tissues and adjacent tissues. (C) Relative messenger RNA (mRNA) expression of writers and erasers in the above 13 paired tissues. (D) The mRNA expression of METTL3 in 136 paired gastric carcinoma tissues and adjacent tissues. (E) METTL3 expression in GES-1, pGCC, and cancer cell lines at the protein level. (F) METTL3 protein expression in four paired tumor tissues and adjacent tissues. *p < 0.05, **p < 0.01, ***p < 0.001. ns, non-significant.