Table 2.

Univariate and multivariate analysis of OS in 196 patients (TNM stage I–IV) and DFS in 156 patients (TNM stage I–III).

Variables	OS				DFS
	Univariate		Multivariate		Univariate		Multivariate
	HR (95% CI)	P-value	HR (95% CI)	P-value	HR (95% CI)	P-value	HR (95% CI)	P-value
Gender	1.104 (0.694–1.756)	0.676			1.636 (0.921–2.907)	0.093
Male vs. Female
Age	0.842 (0.547–1.295)	0.433			0.846 (0.523–1.224)	0.495
>55 vs. ≤55
Tumor size	1.642 (1.064–2.532)	0.025*			1.652 (1.016–2.688)	0.043*
>5 cm vs. ≤5 cm
Grade	0.733 (0.459–1.172)	0.733			1.726 (0.881–3.382)	0.111
III vs. I–II
Invasion depth	2.851 (1.242–6.574)	0.014*			2.446 (1.057–5.658)	0.037*
Whole layer vs. Not whole layer
Neural invasion	2.153 (1.211–3.892)	0.009*			1.956 (1.085–3.528)	0.026*
Yes vs. No
Vessel invasion	2.456 (1.470–4.102)	0.001*			1.904 (1.136–3.192)	0.015*
Yes vs. No
T stage	3.781 (1.384–10.330)	0.009*			3.429 (1.248–9.422)	0.005*
T3−4 vs. T1−2
N stage	4.060 (2.092–7.875)	<0.001*	2.175 (1.046–4.521)	0.037	2.931 (1.568–5.480)	0.001*	2.029 (1.018–4.046)	0.044
N1−3 vs. N0
M stage	4.965 (3.098–7.981)	<0.001*	2.321 (1.361–3.959)	0.002
M1 vs. M0
TNM stage	4.730 (2.949–7.587)	<0.001*	2.408 (1.337–4.334)	0.003	2.692 (1.635–4.384)	<0.001*	1.727 (1.003–2.973)	0.045
III–IV vs. I–II
METTL3	2.177 (1.414–3.353)	<0.001*	1.741 (1.123–2.698)	0.013	1.991 (1.226–3.324)	0.001*	1.936 (1.189–3.512)	0.008
High vs. Low expression

HR, hazard ratio; CI, confidence interval; TNM, tumor-node-metastasis. *p < 0.05.