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. 2020 Feb 26;11:20. doi: 10.3389/fneur.2020.00020

Table 4.

The results from general linear mixed models of cognitive impairment and the covariates on BI.

Variables BI
Model I Model II Model III
Estimate 95% CI p Estimate 95% CI p Estimate 95% CI p
Lower Upper Lower Upper Lower Upper
Intercept 85.2695 77.6462 92.8927 <0.0001 94.5132 85.8905 103.14 <0.0001 99.9090 90.7451 109.07 <0.0001
Time 3.1211 2.4040 3.8381 <0.0001 1.5323 0.5907 2.4739 0.0018 1.5125 0.5844 2.4407 0.0018
Cognitive impairment −9.9874 −16.7709 −3.2039 0.0042 −9.2206 −16.8047 −1.6365 0.0176 −8.1067 −15.0944 −1.1190 0.0233
NIHSS (at admission) −1.9630 −3.3060 −0.6200 0.0045 −1.6476 −2.9887 −0.3066 0.0164
NIHSS (admission) * time 0.3397 0.1400 0.5394 0.0010 0.2741 0.07145 0.4768 0.0084
Receiving rehabilitation −24.1535 −36.7958 −11.5112 0.0002 −21.3089 −34.2312 −8.3866 0.0014
Receiving rehabilitation * time 2.8582 0.9182 4.7982 0.0042 2.5883 0.5979 4.5787 0.0112
Premorbid disability −7.0704 −13.0672 −1.0736 0.0212
Hypertension −5.8778 −12.0358 0.2802 0.0612
Pain (four time points) −2.9591 −4.6123 −1.3060 0.0006
Pain * time 0.3858 −0.2206 0.9922 0.2104

For the BI, (1) model I was a basic model adjusted for time and cognitive impairment; (2) model I plus NIHSS, receiving rehabilitation 1 month after onset (model II); and (3) model II plus premorbid disability, hypertension, and pain (model III).

BI, Barthel Index; NIHSS, National Institutes of Health Stroke Scale.