Fig. 2.

Brimonidine (a) and timolol (b) concentrations in the aqueous humor after the administration of fixed-combination ophthalmic solution of 0.1% brimonidine tartrate and 0.5% timolol (combination group), 0.1% brimonidine tartrate ophthalmic solution (BMD) (brimonidine group), or 0.5% timolol ophthalmic solution (TIM) (timolol group) or concomitant administration of these single drugs (concomitant group) in rabbits. A 35-µl drop of ophthalmic solution was topically applied to each eye of the rabbits. In the concomitant group, BMD was administered 5 min after TIM instillation. Data are presented as mean (n = 2) or mean ± standard deviation (n = 3–6)