Table 1.
Pharmacokinetic parameters of brimonidine and timolol in the aqueous humor after concomitant administration of 0.1% brimonidine ophthalmic solution and 0.5% timolol ophthalmic solution with or without administration interval in rabbits
| Group | Brimonidine | Timolol | ||||
|---|---|---|---|---|---|---|
| Tmax (h) | Cmax (ng/ml) | AUC0–2 (ng·h/ml) | Tmax (h) | Cmax (ng/ml) | AUC0–2 (ng·h/ml) | |
| Concomitant | ||||||
| 5-min interval | 1 | 622 ± 78 | 821 ± 41 | 1 | 4990 ± 4520 | 6300 ± 2040 |
| Non-interval | 0.5 | 340 ± 105 | 463 ± 77 | 0.5 | 2900 ± 840 | 3920 ± 540 |
Cmax is presented as mean ± standard deviation (n = 3). AUC0–2 is presented as mean ± standard error (n = 3)
Tmax time to maximum concentration, Cmax maximum concentration, AUC0–2 area under the curve from time 0–2 h