Table 2.
Pharmacokinetic parameters of brimonidine and timolol in the aqueous humor after topical administration to rabbits
| Group | Brimonidine | Timolol | ||||
|---|---|---|---|---|---|---|
| Tmax (h) | Cmax (ng/ml) | AUC0–4 (ng·h/ml) | Tmax (h) | Cmax (ng/ml) | AUC0–4 (ng·h/ml) | |
| Combination | 0.5 | 393 ± 140 | 599 ± 91 | 1 | 3410 ± 2020 | 5550 ± 750 |
| Brimonidine | 0.5 | 395a | 595 ± 93 | – | – | – |
| Timolol | – | – | – | 0.25 | 2580 ± 1080 | 3520 ± 540 |
| Concomitant | 1 | 673 ± 201 | 911 ± 93 | 0.5 | 3560 ± 2020 | 5160 ± 530 |
Cmax is presented as mean ± standard deviation (n = 3–6). AUC0–4 is presented as mean ± standard error (n = 2–6)
Tmax time to maximum concentration, Cmax maximum concentration, AUC0–4 area under the curve from time 0–4 h
aThis value is presented as mean (n = 2)