Table 3.

Pharmacokinetic parameters of brimonidine and timolol in the plasma after topical administration to rabbits

Group	Brimonidine			Timolol
	Tmax (h)	Cmax (pg/ml)	AUC0–4 (pg·h/ml)	Tmax (h)	Cmax (pg/ml)	AUC0–2 (pg·h/ml)
Combination	0.33	1190 ± 230	1540 ± 100	0.33	11,300 ± 3500	15,700 ± 2200
Brimonidine	0.43	947 ± 70	1380 ± 100	–	–	–
Timolol	–	–	–	0.33	11,400 ± 2900	10,300 ± 1200

T_max is presented as mean (n = 3). C_max, AUC_0–4, and AUC_0–2 are presented as mean ± standard deviation (n = 3)

T_max time to maximum concentration, C_max maximum concentration, AUC_0–4 or AUC_0–2 area under the curve from time 0 to 4 or 2 h