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. 2020 Mar 3;4:5. doi: 10.1038/s41698-020-0110-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Correlation between ESR1 mRNA and LINC00263 LncRNA levels in ovarian cancer. Data from GEO database (GSE14407). b Correlation between AR mRNA and LINC00263 LncRNA levels in prostate cancer. Data from TCGA database. c, d The expression of LINC00263 in MCF-7 cells after treatment with 100 nM estrogen (GSE119087) c or estradiol (GSE11352) d from the GEO database. e The expression of LINC00263 in LNCaP cells after AR gene knock down. Data from GEO database (GSE11428). f The expression of LINC00263 in LNCaP cells after DHT treatment. Data from the GEO database (GSE7868). g, h RT-qPCR analysis was conducted to detect the level of LINC00263 after treatment with E2 in MCF-7 cells g and A549 cells h. i The expression of LINC00263 in normal women during the menstrual cycle. Data from the GEO database (GSE6364). j The expression of LINC00263 in the vagina of postmenopausal women after treatment with E2. Data from the GEO database (GSE11622). k, l the expression of LINC00263 in ER negative k or ER positive l ovarian cells after treatment with E2. Data from the GEO database (GSE22600). m, n The expression of LINC00263 in tamoxifen-sensitive m and tamoxifen-resistant n after treatment with E2 or tamoxifen or E2 and tamoxifen. Data from the GEO database (GSE26459). Data are shown as the mean ± SEM; n ≥ 3 independent experiments, two-tailed Student’s t-test: ns nonsignificant (P > 0.05), *P < 0.05, **P < 0.01, ***P < 0.001.