Fig. 7. The xenograft model of A549-LINC00263 and schematic diagram predicting the role of LINC00263.

a–c Nude mice after the injection of A549 stably expressing the LINC00263 expression are shown. Tumor formation was monitored at the indicated times; images a, volume b and weights c were recorded (n = 8). Data are shown as the mean ± SEM; n ≥ 3 independent experiments, two-tailed Student’s t-test: ns nonsignificant (P > 0.05), *P < 0.05, **P < 0.01, ***P < 0.001. d LINC00263 could promote p65 translocation into the nucleus to activate the NF-κB pathway signaling through interaction with IKKα. Estrogen binding with estrogen receptor to inhibit p65 entry into the nucleus that can inhibit the function of LINC00263.