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. 2020 Mar 3;11:1168. doi: 10.1038/s41467-020-14962-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Western blot representative images (left panel) and quantification (right panel) of LC3 protein levels, LC3-I and LC3-II forms (LC3-II/LC3-I ratio), and tubulin as a loading control from hepatic protein extracts from healthy male Terc^+/+ and G2 Terc^−/− mice fed rapamycin or control diet during 2 months. b, c Mitochondrial DNA copy number as defined by analysis of the Cyt-b and Nd1 mitochondrial genes in liver (b) and skeletal muscle (c) from rapamycin or control fed Terc^+/+ and G2 Terc^−/− mice at the HEP. d Western blot representative images (upper panel) and quantification (lower panel) of the OXPHOS complexes V (ATP5A), III (UQCRC2), IV (MTCO1), and II (SDHB) protein levels in liver from rapamycin- or control-fed Terc^+/+ and G2 Terc^−/− mice at the HEP. Error bars represent the SE. n = number of mice. Statistical significance was determined by one-way Anova with post hoc Tukey test. *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001; n.s. not significant. Source data are provided as a Source Data file.