Table 2.
Parameters | Intravenous (i.v) | Oral (p.o.) |
---|---|---|
Dose (mg/kg) | 5 | 5 |
Tmax (h) | - | 0.80±0.67 |
Cmax (ng/mL) | - | 137±100 |
t1/2 (h) | 1.37±0.29 | 1.13±0.27 |
CL (L/h/kg) | 8.66±4.51 | - |
Vss (L/kg) | 12.9±4.66 | - |
AUC8h (h·ng/mL) | 661±253 | 292±202 |
AUC∞ (h·ng/mL) | 677±264 | 302±209 |
MRT (h) | 1.58±0.32 | 1.9±0.55 |
F (%) | - | 38.2 |
Data represent mean±standard deviation.
Tmax, the time to reach a peak concentration; Cmax, peak plasma concentration; t1/2, terminal elimination half-life; CL, clearance; Vss, distribution volume at steady state; AUC8h, area under the plasma concentration-time curve values of LMT-28 during 8 h; AUC∞, able to cover approximately 96.7% of the total AUC; MRT, mean residence time; F, bioavailability.