Table 1.
Potential LC3 interaction region sequences identified in human ATG2A and ATG2B protein sequences
| LIR number | Gene | Potential LIR sequence | Amino acid position (WxxL) | Mutant LIR interaction with GST‐LC3/GABARAPs? |
|---|---|---|---|---|
| 1 | ATG2A | GTSEPEYTEILT | 536–539 | +++ |
| 2 | ATG2A | SLHQSTFSTLVT | 926–929 | − |
| 3 | ATG2A | GQPGLGYFCLEA | 981–984 | +++ |
| 4 | ATG2A | HSQLLEFLDVLDD | 1,092–1,095 | +++ |
| 5 | ATG2A | TLDSDEFCILDAP | 1,362–1,365 | − |
| 1 | ATG2B | SSDDFDWPRIVL | 845–848 | +++ |
| 2 | ATG2B | LPNKSFYEKLYN | 954–957 | Present on alpha helix |
| 3 | ATG2B | PSPVETFENISY | 979–982 | Not expressed |
| 4 | ATG2B | EETLQYFSTVDP | 1,026–1,029 | ++ |
| 5 | ATG2B | INLSRDYVRVMD | 1,306–1,309 | Not expressed |
| 6 | ATG2B | PTENDDFCILFAP | 1,491–1,494 | − |