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. 2020 Jan 13;21(3):e48328. doi: 10.15252/embr.201948328

Figure EV5. Overexpressing Tau increases expression of survival genes.

Figure EV5

  • A
    The hippocampal neurons (7 div) transfected with lenti‐GFP‐Tau or the empty vector for 5 div and the increased mRNA levels of bcl2 and survivin (survival molecular markers) and dkk1 (Wnt/β‐cat downstream marker) were detected by Q‐PCR (n = 6 biological replicates each group).
  • B
    The increased mRNA levels of bcl2, survivin, and dkk1 in the hippocampi of 10‐month‐old Tau transgenic mice (Tau+) compared with Tau knockout mice (Tau−) detected by Q‐PCR (n = 4 biological replicates each group).
  • C
    Expressing Tau‐k18(−) abolishes Tau‐induced upregulation of bcl2, survivin, and dkk1 mRNA levels in HEK293 cells measured by Q‐PCR (n = 6–9 biological replicates each group).
Data information: Data are presented as mean ± SEM; *P < 0.05; **P < 0.01; ***P < 0.001 vs. Vec (A), or vs. Tau− (B), or vs. Tau (C). Data were analyzed by Student's t‐test (A and B) or one‐way ANOVA (C).