TABLE 3.
Patient Characteristics and Their Relationship to Different Outcomes Following LA in Univariate Analysis
| Factor | PFS | DSPFS | OS | DSOS | |||||
|---|---|---|---|---|---|---|---|---|---|
| No (%) or median (range) | Median (mo) | Pa | Sub-hazard ratio (95% C.I) | Pb | Median (mo) | Pa | Sub-hazard ratio (95% C.I) | Pb | |
| Gender | |||||||||
| Female | 10 (42%) | 4.7 | .59 | 1.38 (0.56-3.41) | .48 | 24.9 | .76 | 3.10 (0.95-10.2) | .06 |
| Male | 14 (58%) | 4.2 | 14.4 | ||||||
| Age (yr) | 54 (34-75) | .61 | 0.98 (0.95-1.02) | .30 | .39 | 1.00 (0.96-1.04) | .98 | ||
| < 70 | 18 (75%) | 4.3 | .63 | 0.43 (0.13-1.40) | .16 | 21.4 | .03 | 1.31 (0.35-4.96) | .69 |
| ≥ 70 | 6 (25%) | 4.8 | 8.4 | ||||||
| Pre-op KPSc | |||||||||
| 60-70 | 7 (29%) | 3.3 | .008 | 0.89 (0.60-1.32) | .16 | 7.4 | .15 | 0.86 (0.44-1.70) | .67 |
| 80 | 8 (33%) | 3.5 | 14.4 | ||||||
| 90-100 | 9 (38%) | 9.0 | 15.2 | ||||||
| Tumor location | |||||||||
| Lobar | 13 (54%) | 4.5 | .31 | 0.79 (0.33-1.92) | .61 | 14.4 | .65 | 0.47 (0.15-1.41) | .17 |
| Othersd | 11 (46%) | 4.1 | 22.4 | ||||||
| KI 67 (%)e | 20% (3-80%) | .87 | 1.01 (0.99-1.02) | .31 | .42 | 1.02 (1.00-1.04) | .03 | ||
| < 20% | 5 (28%) | 5.7 | .08 | 3.09 (0.74-12.9) | .12 | 15.2 | .26 | 4.05 (0.57-28.8) | .16 |
| ≥ 20% | 13 (72%) | 4.1 | 8.5 | ||||||
| Tumor volume (cm3) | 9.33 (1.3-62.8) | .04 | 1.04 (1.02-1.07) | .0006 | .61 | 1.04 (1.01-1.08) | .02 | ||
| < 11 | 16 (67%) | 5.3 | .06 | 2.26 (0.84-6.08) | .11 | 21.4 | .04 | 3.32 (0.85-12.9) | .08 |
| ≥ 11 | 8 (33%) | 3.6 | 8.1 | ||||||
PFS: progression-free survival, DSPFS: disease specific progression-free survival, OS: overall survival, DSOS: disease specific overall survival, C.I: confidence interval, KPS: Karnofsky performance status
aLog rank test if 2 categories, Wald test from proportional hazards model if > 2 categories or if the factor is measured on a continuum
bGray's test. The first group listed is the reference; ratios > 1 indicate the risk of death is greater in the second group; ratios < 1 that it is less. For factors measured factors or factors with > 2 categories the hazard ratio represents the change in risk for a 1 unit (category) increment
c3 patients were KPS 60; 1 was KPS 100
dThalamus (n = 7), callosum (n = 2), insula (n = 2)
emissing for 6 patients