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. 2020 Jan 10;28(3):794–804. doi: 10.1016/j.ymthe.2020.01.003

Figure 2.

Figure 2

Active Release of Immunogenic Molecules and Chemokines by OBP-502 In Vitro

(A) Extracellular ATP secreted from CT26 and PAN02 cells was measured using a luminescence assay 24 h after OBP-502 treatment (0, 500, and 1,000 MOI). *p < 0.001. (B) Extracellular HMGB1 secreted from CT26 and PAN02 cells was measured using an ELISA 24 h after OBP-502 treatment (0, 500, and 1,000 MOI). *p < 0.001, **p < 0.005. (C) Cytokines and chemokines secreted from CT26 cells were measured using multi-cytokine and chemokine assays 24 h after OBP-502 treatment (0 and 1,000 MOI), and ratio of 1,000 MOI to 0 MOI was plotted for each cytokine or chemokine. (D) CCL5/RANTES secreted from CT26 cells and PAN02 cells was measured using an ELISA 24 h after OBP-502 treatment (0, 500, and 1,000 MOI). *p < 0.001.