Figure 3.

Liver Gene Transfer Can Drive Transgene Immune Tolerance

Tolerance to a variety of transgenes expressed in the liver is mediated by a variety of mechanisms. Tregs are a common denominator of liver tolerance, as they mediate the suppression of both humoral and T cell-mediated transgene immune responses. Additional mechanisms include anergy, exhaustion, and deletion of reactive T cells. Key to tolerance induction appears to be a robust transgene expression in hepatocytes. Adapted from Sherman et al.⁹²