Table 2.
Age-adjusted and multivariable-adjusted annual mean changes in eGFR.
| Group | Subgroup | Number of patients | Age-adjusted annual decline of eGFR | 95% CI | Multivariable-adjusted annual decline of eGFR | 95% CI | p value |
|---|---|---|---|---|---|---|---|
| Total | 1383 | −1.70*** | (−2.10, −1.30) | −1.79*** | (−2.20, −1.38) | ||
| Male | 719 | −1.57*** | (−2.11, −1.02) | −1.77*** | (−2.34, −1.21) | p = 0.889 | |
| Female | 664 | −1.84*** | (−2.42, −1.27) | −1.79*** | (−2.38, −1.20) | ||
| Tertile of HbA1c_CV | 1194 | ||||||
| Low | 397 | −1.17*** | (−1.85, −0.49) | −0.99* | (−1.67, −0.31) | p = 0.01 | |
| Middle | 399 | −1.75*** | (−2.41, −1.09) | −1.73*** | (−2.38, −1.08) | ||
| High | 398 | −2.66*** | (−3.43, −1.90) | −2.53*** | (−3.28, −1.78) | ||
| Baseline eGFR | |||||||
| Baseline eGFR ⩾ 60 | Tertile of HbA1c_CV | 1193 | |||||
| Low | 241 | −1.70*** | (−2.30, −1.09) | −1.50*** | (−2.12, −0.89) | p = 0.019 | |
| Middle | 241 | −1.98*** | (−2.60, −1.37) | −2.02*** | (−2.64, −1.39) | ||
| High | 241 | −3.04*** | (−3.82, −2.27) | −2.95*** | (−3.75, −2.16) | ||
| Baseline eGFR < 60 | Tertile of HbA1c_CV | ||||||
| Low | 156 | −0.35 | (−1.16, −0.46) | −0.21 | (−1.04, 0.61) | p = 0.007 | |
| Middle | 157 | −1.29*** | (−2.01, −0.58) | −1.29*** | (−1.98, −0.59) | ||
| High | 157 | −1.92*** | (−2.65, −1.19) | −1.94*** | (−2.66, −1.21) | ||
| Baseline HbA1c | |||||||
| Baseline HbA1c < 7 | Tertile of HbA1c_CV | 1195 | |||||
| Low | 112 | −0.63 | (−1.93, 0.65) | −0.51 | (−1.76, 0.74) | p = 0.193 | |
| Middle | 113 | −0.77 | (−2.13, 0.58) | −0.89 | (−2.19, 0.40) | ||
| High | 112 | −1.87* | (−3.18, −0.56) | −2.07* | (−3.47, −0.67) | ||
| 7<Baseline HbA1c < 9 | Tertile of HbA1c_CV | ||||||
| Low | 189 | −1.66*** | (−2.56, −0.76) | −1.36* | (−2.29, −0.43) | p = 0.300 | |
| Middle | 189 | −1.56*** | (−2.47, −0.65) | −1.71*** | (−2.68, −0.75) | ||
| High | 189 | −2.72*** | (−3.73, −1.70) | −2.46*** | (−3.43, −1.49) | ||
| Baseline HbA1c ⩾ 9 | Tertile of HbA1c_CV | ||||||
| Low | 96 | −1.87* | (−3.14, −0.60) | −1.61* | (−2.82, −0.41) | p = 0.182 | |
| Middle | 97 | −1.98* | (−3.26,−0.70) | −1.80* | (−3.14,−0.46) | ||
| High | 97 | −3.27*** | (−4.80, −1.75) | −3.32*** | (−4.97, −1.66) | ||
Adjusted for gender, the number of OADs, insulin usage, HTN medication, hyperlipidemia medication, age, baseline HbA1c (%), systolic blood pressure (mmHg).
CI, confidence interval; CV, coefficient of variation; eGFR, estimated glomerular filtration rate; HbA1c, glycated hemoglobin; HTN, hypertension; OAD, oral anti-diabetic drug.
*
p < 0.05 ***p < 0.001. compared with baseline renal function.