Figure 5.

The histoarchitecture of the normal control and kolaviron treated only (KV 100 mg/kg/bw) rats kidneys showed normal glomerulus and tubules with usual morphology (Figure 5 (CN) and (100 KV)). However, histological analysis of the kidneys from DF-treated rats showed distorted renal corpuscles with hyper-infiltration of the glomerulus and increased mesangial matrix as well as severe and widespread of necrosis of the renal tubules (particularly proximal tubules), which lead to loss of tubular cellular constituents, with dilatation of renal vessels and tubular cell desquamation and intraluminal cast formation and infiltration of inflammatory leukocytes (Figure 5 (DF)). Histological analysis of the kidneys from DF-treated rats pretreated with kolaviron showed less histopathological renal alteration (100 KV + DF and 200 KV + DF). DF indicates Diclofenac; KV, kolaviron; 100 KV, 100 mg/kg of kolaviron; 200 KV, 200 mg/kg of kolaviron.