Table 1.
Effect of KV on Kidney and Liver Biochemical in DF-Induced Hepatorenal Toxicity.a
| Groups | Creatinine (mg/dL) | Urea (mg/dL) | AST (U/L) | ALT (U/L) | ALP (U/L) | Total Bilirubin (µmol/L) |
|---|---|---|---|---|---|---|
| Control | 0.76 ± 0.07 | 19.91 ± 1.02 | 50.66 ± 3.28 | 26.13 ± 5.73 | 99.28 ± 6.28 | 4.31 ± 0.85 |
| 100KV | 0.36 ± 0.03b | 15.07 ± 1.14c | 53.06 ± 4.21 | 27.76 ± 3.12 | 100.9 ± 6.18 | 4.89 ± 1.11 |
| DF | 1.77 ± 0.06d | 146.40 ± 15.60d | 110.4 ± 10.42b | 81.02 ± 7.95d | 200.1 ± 27.72d | 13.32 ± 1.24d |
| 100KV + DF | 0.88 ± 0.10e | 25.00 ± 2.34f | 60.08 ± 2.28e | 31.26 ± 3.06e | 118.6 ± 4.41e | 8.01 ± 1.00c,g |
| 200KV + DF | 0.79 ± 0.05e | 20.41 ± 1.30f | 56.78 ± 3.57e | 28.23 ± 2.16f | 110.6 ± 5.44e | 4.90 ± 0.91f |
Abbreviations: ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; DF, diclofenac; KV, kolaviron; SEM, standard error of mean; 100KV, 100 mg/kg of kolaviron; 200KV, 200 mg/kg of kolaviron.
a Data are expressed as means ± SEM.
b P < .01 is significantly different from control.
c P < .05 is significantly different from control.
d P < .001 is significantly different from control.
e P < .01 significantly different from DF.
f P < .001 significantly different from DF.
g P < .05 significantly different from DF.