Table 2.
Effect of KV on Kidney Antioxidant Activities and MDA Levels in DF-Induced Hepatorenal Toxicity.a
| Groups | SOD (µ/mg tissue) | CAT (µM/mg tissue) | GSH (µg/mg tissue) | MDA (nM/mg tissue) | H2O2 (nM/g tissue) |
|---|---|---|---|---|---|
| Control | 80.11 ± 1.29 | 2.24 ± 0.19 | 5.92 ± 0.47 | 10.92 ± 0.86 | 17.77 ± 1.04 |
| 100KV | 77.35 ± 1.62 | 2.11 ± 0.42 | 5.56 ± 0.40 | 11.86 ± 1.13 | 17.64 ± 1.53 |
| DF | 111.20 ± 3.36b | 4.31 ± 0.28c | 1.39 ± 0.15b | 25.15 ± 1.05b | 34.00 ± 2.03c |
| 100KV + DF | 78.65 ± 0.47d | 2.55 ± 0.58e | 5.08 ± 0.36d | 12.33 ± 1.06e | 20.21 ± 1.33e |
| 200KV + DF | 79.01 ± 1.25d | 2.20 ± 0.28e | 5.53 ± 0.54d | 12.55 ± 1.24e | 19.01 ± 0.45d |
Abbreviations: CAT, catalase; DF, diclofenac; GSH, reduced glutathione; KV, kolaviron; MDA, malondialdehyde; SEM, standard error of mean; SOD, superoxide dismutase; 100KV, 100 mg/kg of kolaviron; 200KV, 200 mg/kg of kolaviron.
a Data are expressed as means ± SEM.
b P < .001 is significantly different from control.
c P < .01 is significantly different from control.
d P < .001 is significantly different from DF.
e P < .01 is significantly different from DF.