Table 4.
Effect of KV on MPO, TNF-α, IL-6, PLT/LYM, and NEU/LYM in DF-Induced Hepatorenal Toxicity.a
| Groups | Kidney MPO (U/mg protein) | Liver MPO (U/mg protein) | TNF-α (pg/ml) | IL-6 (pg/ml) | PLT/LYM | NEU/LYM |
|---|---|---|---|---|---|---|
| Control | 7.64 ± 3.04 | 5.94 ± 2.04 | 6.32 ± 1.17 | 13.27 ± 1.93 | 4.89 ± 0.09 | 0.15 ± 0.00 |
| 100KV | 7.92 ± 2.46 | 7.04 ± 3.20 | 7.01 ± 1.66 | 12.91 ± 1.09 | 5.32 ± 0.15 | 0.19 ± 0.01 |
| DF | 30.01 ± 5.21b | 24.94 ± 6.04b | 25.83 ± 3.09b | 28.43 ± 3.79c | 10.89 ± 0.98c | 0.53 ± 0.02c |
| 100KV + DF | 15.98 ± 5.98d,e | 10.94 ± 3.44d,f | 14.23 ± 1.91d,f | 13.93 ± 1.64f | 5.26 ± 0.82g | 0.21 ± 0.00g |
| 200KV + DF | 10.08 ± 4.35e | 10.06 ± 3.10d,f | 13.65 ± 1.36d,f | 12.99 ± 1.31f | 4.59 ± 0.10f | 0.16 ± 0.01f |
Abbreviations: DF, diclofenac; IL-6, interleukin 6; KV, kolaviron; MPO, myeloperoxidase; NEU/LYM, neutrophil/lymphocyte; PLT/LYM, platelet/lymphocyte; SEM, standard error of mean; TNF-α, tumor necrosis factor α; 100KV, 100 mg/kg of kolaviron; 200KV, 200 mg/kg of kolaviron.
a Data are expressed as means ± SEM.
b P < .001 significantly different from control.
c P < .01 significantly different from control.
d P < .05 significantly different from control.
e P < .001 significantly different from DF.
f P < .01 significantly different from DF.
g P < .05 significantly different from DF.