Table 4.

Effect of KV on MPO, TNF-α, IL-6, PLT/LYM, and NEU/LYM in DF-Induced Hepatorenal Toxicity.^a

Groups	Kidney MPO (U/mg protein)	Liver MPO (U/mg protein)	TNF-α (pg/ml)	IL-6 (pg/ml)	PLT/LYM	NEU/LYM
Control	7.64 ± 3.04	5.94 ± 2.04	6.32 ± 1.17	13.27 ± 1.93	4.89 ± 0.09	0.15 ± 0.00
100KV	7.92 ± 2.46	7.04 ± 3.20	7.01 ± 1.66	12.91 ± 1.09	5.32 ± 0.15	0.19 ± 0.01
DF	30.01 ± 5.21b	24.94 ± 6.04b	25.83 ± 3.09b	28.43 ± 3.79c	10.89 ± 0.98c	0.53 ± 0.02c
100KV + DF	15.98 ± 5.98d,e	10.94 ± 3.44d,f	14.23 ± 1.91d,f	13.93 ± 1.64f	5.26 ± 0.82g	0.21 ± 0.00g
200KV + DF	10.08 ± 4.35e	10.06 ± 3.10d,f	13.65 ± 1.36d,f	12.99 ± 1.31f	4.59 ± 0.10f	0.16 ± 0.01f

Abbreviations: DF, diclofenac; IL-6, interleukin 6; KV, kolaviron; MPO, myeloperoxidase; NEU/LYM, neutrophil/lymphocyte; PLT/LYM, platelet/lymphocyte; SEM, standard error of mean; TNF-α, tumor necrosis factor α; 100KV, 100 mg/kg of kolaviron; 200KV, 200 mg/kg of kolaviron.

^a Data are expressed as means ± SEM.

^b P < .001 significantly different from control.

^c P < .01 significantly different from control.

^d P < .05 significantly different from control.

^e P < .001 significantly different from DF.

^f P < .01 significantly different from DF.

^g P < .05 significantly different from DF.