Table 5.
Effect of KV on Hematological Indices in DF-Induced Hepatorenal Toxicity.a
| Parameters | Control | 100KV | DF | 100KV + DF | 200KV + DF |
|---|---|---|---|---|---|
| WBC (×103/µL) | 7.98 ± 0.62 | 6.86 ± 0.90 | 3.54 ± 0.63b | 4.86 ± 0.99 | 6.24 ± 1.17c |
| LYM % | 85.74 ± 0.79 | 84.40 ± 4.75 | 70.98 ± 4.97d | 83.44 ± 3.17c | 95.24 ± 3.91e |
| NEUT % | 12.42 ± 1.09 | 15.32 ± 8.42 | 32.14 ± 7.62b | 17.36 ± 5.21c | 14.06 ± 1.81e |
| RBC (×106/µL) | 7.48 ± 0.24 | 7.82 ± 0.26 | 4.08 ± 0.35d | 6.99 ± 0.36c | 7.32 ± 0.37c |
| HGB (g/dL) | 15.52 ± 0.61 | 15.08 ± 0.53 | 10.10 ± 0.65d | 14.21 ± 0.95c,d | 15.04 ± 0.70c |
| PCV (%) | 47.76 ± 2.48 | 47.30 ± 1.44 | 21.28 ± 3.65d | 36.26 ± 2.38c,d | 43.62 ± 1.91c |
| MCV (fL) | 60.02 ± 0.99 | 60.56 ± 0.47 | 60.38 ± 0.87 | 60.48 ± 0.75 | 59.42 ± 0.73 |
| MCH (pg) | 19.54 ± 0.19 | 19.60 ± 0.08 | 20.02 ± 2.23 | 18.96 ± 0.51 | 19.38 ± 0.11 |
| MCHC (g/dL) | 32.30 ± 0.31 | 32.46 ± 0.18 | 31.64 ± 0.56 | 31.40 ± 0.56 | 32.84 ± 0.76 |
| PLT (×103/µL) | 410.40 ± 58.63 | 424.00 ± 34.06 | 700.00 ± 53.93b | 438.40 ± 147.01e | 430.60 ± 209.23e |
Abbreviations: DF, diclofenac; HB, hemoglobin; KV, kolaviron; LYM, lymphocyte; MCHC, mean corpuscular hemoglobin; MCV, mean corpuscular volume; NEU, neutrophil; PCV, packed cell volume; PLT, platelet counts; RBC, red blood cell; SEM, standard error of mean; WBC, white blood cell; 100KV, 100 mg/kg of kolaviron; 200KV, 200 mg/kg of kolaviron.
a Data are expressed as means ± SEM.
b P < .01 significantly different from control.
c P < .05 significantly different from DF.
d P < .05 significantly different from control.
e P < .01 significantly different from DF.