Table 1. K_d and IC₅₀ values for series of inhibitors (4–10) and SAH against PRMT1 and CARM1 measured using ITC and enzyme activity assays, respectively.

Inhibitor	Kd ± standard error (µM)		IC50 (95% confidence interval) (µM)
	PRMT1	CARM1	PRMT1	CARM1
4	10.2 ± 0.996	3.32 ± 0.335	7.2 (3.5–15.0)	2.3 (1.8–3.0)
5	4.02 ± 0.453	7.18 ± 0.557	11.8 (9.0–15.5)	8.7 (6.9–10.8)
6	9.99 ± 1.89	9.80 ± 1.83	11.6 (4.9–27.2)	17.7 (13.5–23.2)
7	32.2 ± 3.531	38.1 ± 9.61	22.0 (14.4–33.5)	24.1 (15.4–37.6)
8	10.2 ± 4.21	2.30 ± 0.162	22.0 (15.7–30.8)	0.7 (0.5–1.0)
9	15.3 ± 1.57	1.14 ± 0.411	11.1 (5.6–21.8)	0.3 (0.1–1.1)
10	43.7 ± 14.92	1.11 ± 0.132	25.3 (17.3–37.0)	0.8 (0.6–1.0)
SAH	0.709 ± 0.057	0.775 ± 0.111	0.5 (0.2–1.0)	0.2 (0.1–0.4)

¹Stoichiometry fixed to 0.5.

²This K_d is derived from a competition experiment with SAH as the K_d was not accessible through direct titration.